isystem.exe is a Trojan.Chorus-B. isystem.exe changes settings for Microsoft Internet Explorer. Related files: %Windows%\htmlsync.exe %System%\isystem.exe %System%\ldriver.exe %Windows%\zlibc.exe More info: http://www.sophos.com/virusinfo/analyses... Removal: Kill isystem.exe process and remove isystem.exe from Windows startup using antivirus (also check How To Remove section)Startup Optimizer.