msdef.exe is a worm W32.Secefa.A. msdef.exe opens a back door. msdef.exe tries to terminate antiviral programs installed on a user computer. Related files: %System%\msdef.exe %System%\services.exe %System%\ws3lib.exe %Windir%\dodrrr.exe %System%\qwe.bat %System%\ftp.scr More info: http://securityresponse.symantec.com/avc... Removal: Kill msdef.exe process and remove msdef.exe from Windows startup using antivirus (also check How To Remove section)Startup Optimizer.