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Run various antispyware and antivirus checks in safe mode or roll back to a previous setting using SYSTEM RESTORE. Sounds like something loaded in normal Windows (not safe mode) is causing issues. Could be a service or something.
You can also run MSCONFIG from safe mode, and check what is loaded at startup. There may be something suspicious in there that you can remove. In practice, I try and kepe the startup section as clean as possible to keep the machine fast.
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