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Go to Malwarebytes.org, download the latest verion (anti-malware version 1.20). Install it and run it at least twice with quick scan, and one with full scan of all drives. Don't forget to delete the infected files found by malwarebytes. RESTART the PC. Download CCleaner, run it (everyone should run this utility at least once a week). Download Easy Cleaner, install and run the registry cleaner after you have wiped all the bugs in your system. Also, uninstall spybot because it obviously not working. You got a lots of processes running at the same time that is probably why you can't open up task manager easily. Uninstall what you don't need and run the registry cleaner again.
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