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Not really.
So long as you are careful what you do and where you go, you will get the 'no immedaite threats were found and no registry inconsistencies were found' regularly, with the exception of the usual found cookies, TIF's, .log's, MRU, etcetera.
I usually run Spybot and Ad-aware on a daily basis.
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An ounce of prevention is worth more than a pound of cure
Proud Member of the Alliance of Security Analysis Professionals (ASAP) 2006
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