Did you happen to run Group Policy and fool with any thing? Have you tried to switch to classic view and scroll down with the arrow keys and hit enter instead of a mouse?
There is one thing I go by when things like this come up. When it is crazy like this is, check for a virus (Like Sir Cam worm virus). You need to go out on the net to find a tool just for that virus in this case.
Try it, what can it hurt?
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