I also use spybot both at work and at home.
Since I am on the computer from 8-5pm Mon-Fri at work and my computer is always on the internet I was getting these annoying pop ups that spybot was not catching/deleting.
I discovered Superadblocker and it got rid of the annoyance instantly.
Since downloading the superadblocker, I haven't had any annoying problems. I use both spybot and superadblocker and chances are, either one will catch and destroy whatever finds it way onto my computer.
Both programs are easy to use and easy to customize.
I believe you can download a free trial version of superadblocker at download.com.
The only glitch I think I get with superadblocker is that a forum website I visit on a daily basis during my lunch hour is now very slow to load up since I got the superadblocker. I don't know what the blocker is doing to cause this website forum to load up slower now. But, am afraid to take off the blocker because I'll get "Mr. Annoyance" again.

LOL