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Issue #2:
Do you have Spybot? Spybot has a feature called "Immunize". Near the bottom of the "Immunize" window is a box with 3 "Protections", "Lock Hosts file.....", "Lock IE Start Page Setting Against User Changes (Current User)", "Lock IE Control Panel Against Opening From Within IE (Current User)".
If there is a check in one of these last 2 boxes, you'll get the symptoms that you describe.
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