Application Slow-Downs in Windows XP
http://www.scotsnewsletter.com/47.htm
Control Panel > Network Connections > Right-click your main network connection , choose
Properties > Double-click "Internet Protocol (TCP/IP)" > Click Advanced
button > Select WINS tab .
The solution I've seen recommended and posted in various places is to
remove the check mark beside "Enable LMHOSTS lookup" on the WINS tab
and/or "Disable NetBIOS over TCP/IP." People report that the
application slow-downs go away .
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Disable Indexing Services
http://www.tweakxp.com/tweakxp/display.asp?id=1335
http://mywebpages.comcast.net/SupportCD/OptimizeXP.html
Indexing services is a small program that hogs HUGE amounts of RAM and can often make a computer endlessly loud and noisy. This system process indexing and updates lists of the files on your system, so you can search for them quickly, but it's completley unnessesary.
To disable it, go to the Control Panel and click Add/Remove Programs. Click the Add/Remove Window Components. Simply unclick the Indexing services and click next!