Can not delete Temporary Internet Files

[godders]

I have some files in Temporary Internet Files that I can not delete, I have used adaware, Norton disk cleaner and tried deleting and renaming file but has no effect, any ideas

[ESALADUANE]

Files in use can't be deleted and you won't be able to delete some until you reboot.

[godders]

These files have been in the folder for the last few days, ms clean disk locks up useing 99% cpu every time I try to delete them and I have to go to end proccess in Task manager to stop, Norton cleans every thing else except these files every time. They don't seem to be a virus but they do concern me as they should not be there and I can not delete them by hand.